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For example, when switching from carbamazepine, phenytoin, phenobarbital or primidone monotherapy to high dose divalproex sodium monotherapy, 63% of patients experienced no change or a reduction in complex partial seizure rates compared to 54% of patients receiving low dose divalproex sodium

Retrospective analysis of OA progress in type 2 diabetes patients showed the lower ratio of knee arthroplasty in patients treated with metformin, suggesting the possibility of clinical effectiveness
