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In parallel, chondrocytes sense the physical milieu through mechanoreceptors and ion channels that activate downstream pathways, including MAPK and NF-B, thereby regulating inflammation, matrix synthesis and degradation, and apoptosis ( Among emerging therapeutic strategies, targeted cartilage repair has become a major focus

Jayaraman et al., 2020

J Neurosci 14: 13391351, 1994

The formation of a complex in the control reaction, but not in the reaction mixture containing the test compound, indicates that the compound interferes with the interaction of the MMP-29 polypeptide and the interactive binding partner

pii: S0012-1606(17)30201-4

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