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Besides well-established mechanisms that enhance mitochondrial function, we have considered desirable physicochemical properties in selecting the compounds for discussion

The liver is the most common site of metastases and at time of diagnosis 1520% of the patients have already developed liver metastases (Adam, 2007)

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Complex I (NADH: ubiquinone oxidoreductase), the initial enzyme of the mitochondrial electron transport chain, is highly vulnerable to oxidative damage

Aspartame is an artificial sweetener also marketed as NutraSweet, Equal, Sugar Twin and AminoSweet used in more than 6,000 products, including Diet Coke and Diet Pepsi, Kool Aid, Crystal Light, Tango and other artificially sweetened drinks

*Correspondence: Jiang-Hua Li, [email protected] Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers