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L-Carnitine deficiency can cause muscle weakness, metabolic disorders, cardiovascular issues, and in severe cases, neurological symptoms [25]

Hypothyroidism: Cardiovascular endpoints of thyroid hormone replacement

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In patients with renal dysfunction, refractory hypotension, severe metabolic abnormalities, active seizure, or persistent coma, extracorporeal removal by haemodialysis or haemofiltration may be considered, although there are no controlled trials that demonstrate an improvement in outcome with these measures [8890]

& Cummins, T