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Description
In this study, we have revealed the importance of the glutamate-generating metabolism, as shown by a complete depletion of glutamine (Gln) in the medium during H
, insignificant increase
Ferreira PMP, Sousa RWR, Ferreira JRO, Militao GCG, Bezerra DP
Additionally, inhibiting Gln metabolism can reverse chemotherapy resistance
It was observed that CD133 + HCC cells display a notable resistance to cisplatin compared to CD133- HCC cells
The mode of therapeutic action of NAC is believed to involve its hydrolysis in the affected cells to cysteine, leading to increased synthesis of GSH
