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Time course of pulmonary response of rats to inhalation of crystalline silica: NF-B activation, inflammation, cytokine production, and damage

[DOI] [PubMed] [Google Scholar] Myers GJ, Davidson PW, Cox C, Shamlaye CF, Tanner MA, Marsh DO, Cernichiari E, Lapham LW, Berlin M, Clarkson TW
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doi: 10.1038/nrdp.2015.35 503 ZeuthenLHFinkLNFrokiaerH

Werler et al., 2005[106]), with governmental agencies including the FDA and European Medicines Agency (EMA) considering it the safest option for pain and fever relief when used as directed (Bauer et al., 2021[10]

Pharmaceutical formulations for external application need to ensure effective transdermal delivery of the therapeutically relevant substance
