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Intratumoral IL-12 delivery empowers CAR-T cell immunotherapy in a pre-clinical model of glioblastoma

Tryptophan is degraded to kynurenine through the KP, which is the main pathway for tryptophan breakdown [78]

J Clin Invest (2017) 127:313651.10.1172/JCI91301 28 Orthmann-MurphyJLAbramsCKSchererSS

Ioannou and colleagues observed that glutamate exposure reduces LD content in astrocytes, suggesting increased fatty acid utilization and concurrent ATP generation

For more information on energy drinks and teens, see the OPSS article Energy drinks and teens