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Your digestive tract destroys most of the curcumin in turmeric

[Google Scholar] 3.Meister A

In studies that further elucidated the mechanism underlying HAP1s regulation of BDNF transport, it was found that endogenous HAP1 colocalizes with proBDNF and sortilin in cultured cortical neurons

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Studies suggest this phenomenon may arise from IR triggering ROSmediated oxidative stress, activating autophagy signaling pathways to enhance intracellular protein catabolism, leading to free amino acid accumulation [191, 192]

In this context, ISA can also inhibit p38 MAPK and downstream NF-B phosphorylation (Wang et al., 2016)