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Moreover, the complex Gel/(REG NG/LY) is formed by TGF- inhibitor LY3200882 (LY) encapsulated in ROS-responsive nanogels and homogeneously dispersed with regorafenib (REG) in a thermosensitive hydrogel can not only reduce the recruitment of TAMs and MDSCs and promote macrophages polarization from M2 to M1, but also increase the infiltration of CD8 + T cells into tumors thereby effectively inhibiting tumor growth and metastasis (213)

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Additionally, a broad dynamic range covering almost 10 orders of magnitude of concentration has been obtained with the proposed device

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Pathological changes may occur at the level of the cochlea, auditory nerve, brainstem, or auditory cortex and can involve injury to hair cells, cochlear synapses, spiral ganglion neurons, or the stria vascularis