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A well-characterized example of this mechanism is the Keap1Nrf2 signaling axis, illustrated in Fig

But when headaches become regular occurrences were talking two or more per week you may be dealing with something more complicated

VEGF seems to be a signaling protein, reportedly involved in angiogenesis, a process that may be responsible for the formation of new blood vessels from existing vasculature

The key distinction is again the targeted versus systemic approach

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