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The second pathway was from the TC ( m/z = 445) to TC-5 ( m/z = 406) via fracture of the double bond

This observation attributed the role of GSH in regulation of Fe transport under Fe-limiting condition

Presumably, other types of TmGst could play a role in detoxifying other xenobiotics, including antifungal drugs

A key feature that differentiates SAMacs from other profibrotic macrophage populations is their spatial restriction to fibroblastic foci, where active extracellular matrix deposition occurs ( + macrophages are distributed more diffusely within injured interstitial regions, while MARCO + macrophages predominantly reside in the alveolar space and function in surfactant clearance and debris scavenging ( + myofibroblasts, enabling sustained interactions within localized fibrotic microenvironments ( Functionally, SAMacs differ from other profibrotic and tumor-associated macrophage subsets by integrating structural and immunomodulatory roles

This timeline aligns with the natural turnover rate of skin cells and the time needed to influence melanin production pathways

Keywords: dietary supplements, natural products, aging, aging-realated disease, antiaging molecules 1 Introduction The physiological and psychological adaptability of organisms to the environment diminishes with age, leading to functional decline and increased risks of disease and death (Rahman et al., 2021)