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Though inherently microscopic in scale, this field is highly consequential, particularly because modern drug development largely revolves around identifying compounds that target specific proteins

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Key Research Characteristics: Extended half-life (~2030 hours vs ~1215 minutes for native IGF-1) due to reduced IGFBP binding Potent agonist at IGF-1R, studied for roles in cellular proliferation, differentiation, and survival signalling Investigated in models of muscle hypertrophy, neuroprotection, and metabolic regulation 83 amino acid analogue

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For example, among the 25 significantly upregulated TFs and 19 significantly downregulated TFs, POU class 2 homeobox 2 (POU2 F2), interferon regulatory factor 1 and FOS like 2 (FOSL2) are the TFs most highly correlated with PD-L1 expression, contributing to the immunotolerance [69]