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A marked increase in TNF- concentration in granulosa cell cultures of women with endometriosis has been demonstrated [58,59,60,61]

1,2 In a 2005 Cochrane review, patients who received high dosages of oral vitamin B 12 (1 to 2 mg daily) for 90 to 120 days had an improvement in serum vitamin B 12 similar to patients who received intramuscular injections of vitamin B 12

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Therefore, lipid dysregulation within astrocytes could trigger or amplify neuronal vulnerability