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Based on their physical interactions, RSPOs were first described as Wnt signaling agonists 37

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10.1038/jcbfm.2009.112 102 RandoK.TuitK.HannestadJ.GuarnacciaJ.SinhaR

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Together, these findings position DSIP as a multifunctional neuropeptide used in experimental models to investigate the integration of signaling pathways involved in sleep regulation, stress response, neuroprotection, and endocrine coordination

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Results vary depending on the study design, model, and conditions used

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Obesity, cancer, and acetyl-CoA metabolism

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