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acnes lives in the hair follicle (as distinct from the gut), and elevated serum B12 reaches it through the bloodstream

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10.1016/j.ejphar.2019.01.030 106 SeverM.KlicekR.RadicB.BrcicL.ZoricicI.DrmicD.et al (2009)

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Animal studies have shown that when beta-3 adrenergic receptors were genetically removed, chronic AOD-9604 treatment produced no changes in weight or lipolysis, confirming the importance of this pathway

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This is a complex process involving pools and fluxes

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