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Description
SBS17, induced by 5-fluorouracil and an unknown endogenous driver 42 , and SBS18, caused by the mutagenic bypass of 8oxo-guanine, a lesion linked to reactive oxygen species 14 (Fig

Mitochondrial reactive oxygen species (ROS) act as a key regulator, promoting RIPK1 autophosphorylation, which in turn enhances necrosome assembly and MLKL pore-forming capacity, ultimately driving necroptosis (32)

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10.1023/A:1022969828885

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Francis Fellowship to X.Y
