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DiPeso et al

Signs to watch for include: Unexplained fatigue Persistent nausea, vomiting, or diarrhea Loss of appetite Unintended weight loss Yellowish skin Sore mouth or tongue Depression or irritability Behavioral changes Numbness and tingling sensations in the hands and feet Vision changes Mental confusion Should You Consider a B12 Shot

Inherited defects of cobalamin metabolism, in Vitamin B12: Advances and insights
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Animal studies show a more pronounced impact, where AOD9604 increased lipolysis and prevented fat accumulation, but these results dont fully translate to humans (example)