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Several genome-wide association (GWAS) studies have identified a loss-of-function variant of human ANGPTL4 with Glu40-to-Lys substitution (E40K) in the coiled-coil domain which is associated with lower serum triglycerides and reduced risk of coronary artery disease (Figure 1f) [60]

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Science 295 , 821825 (2002)

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