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For cancer cells lacking upregulated EAAT3, it is plausible that other glutamate transporter systems are elevated, and further investigation is required to confirm this

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Introduction Major depressive disorder (MDD) is one of the most common neuropsychiatric disorders worldwide, with an estimated lifetime prevalence of 10.8% [1], increasing to 19% among adolescents [2]

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Studies with Eaat3-knockout mice have demonstrated that the absence of Eaat3 leads to reduced glutathione content in neurons and early onset brain aging due to oxidative stress

For example, in a study described above, Huang et al