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MTHFR protein exists as a homodimer comprising two N-terminal catalytic domains with binding sites for NADPH, methylene-THF, and cofactor FAD-linked to the regulatory domain (C-terminus) (Figure 2B)

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Proposed Survey and Enforcement Criteria As indicated in section 1822(b)(2) of the Act, once in the SFP, a hospice must be surveyed not less than once every 6 months. Based on the TEP discussion, TEP members agreed with the 6-month recertification survey frequency for hospices in the SFP, and we proposed this frequency at proposed 488.1135(c)

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