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The REDEFINE 2 trial examined CagriSema in adults with type 2 diabetes, a population that typically shows less weight loss with GLP-1 therapies
Not only do SCD patients have higher leukocyte counts [44] and serum biomarkers of neutrophil activation, such as CD64 [45], CD11b/CD18 [46], and CD62L [37, 45, 46] compared to non-SCD individuals, their monocytes [47] and platelets [48] are also activated
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The determination of the significance and the therapeutic role of SCFA in IBD needs further investigation
Although the primary objective of this study was met, an imbalance in patient characteristics likely led to our inability to show a significant impact on clinical outcomes
