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3 Toxicity reduction: multitarget intervention of immune-related adverse events 3.1 Prevention and treatment of immune-related pneumonitis and colitis Immune-related pneumonitis (CIP), characterized by excessive inflammatory infiltration in alveoli and interstitium, represents one of the most lethal irAEs ( Immune-related colitisa common severe irAE presenting with diarrhea, abdominal pain, and hematocheziaexhibits dual therapeutic mechanisms under TCM intervention: modulating intestinal immune responses to suppress excessive inflammation while repairing damaged mucosal barriers to promote tissue healing ( 3.2 Mitigation of immune-related cardiac, cutaneous, and other systemic toxicities Immune-related myocarditis, though less frequent, is highly lethal with elevated mortality ( Cutaneous toxicity represents the most common irAEs, presenting as rash, pruritus, and vitiligo, which may progress to Stevens-Johnson syndrome (SJS) or toxic epidermal necrolysis (TEN) ( TCM plays a critical role in managing other systemic toxicities