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The Facts Studies show that creatine supplementation notably improves strength in workouts involving intense muscle contractions and power output, such as lifting, cycling, and sprinting (Kreider et al

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These processes are regulated by guanosine-5triphosphate (GTP)-binding proteins, including mitofusin1/2 (MFN1, MFN2, regulate OMM fusion), optical atrophy 1 (OPA1, promotes IMM fusion), and dynamin-related protein 1 (DRP1, is involved in mitochondrial fission)

It is often used in the treatment of diseases affecting the cardiovascular system, nervous system, liver, and kidney [21, 22]