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It is well accepted that activation of MR in the heart promotes adverse remodeling characterized by inflammation and fibrosis

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Clinical trials of GLP-1-based medications have shown average reductions ranging from moderate to significant percentages of total body weight when combined with dietary changes

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10.1007/s11239-019-01962-2 J

Activation of D 2 receptors has been shown to blunt cocaine sensitization (Beyer and Steketee, 2002), while D 2 antagonists or receptor knockout generally does not greatly alter acute locomotor activation, sensitization, or CPP (Spyraki et al., 1982