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Research suggests the opposite

The OB12 Group Healthcare Centre (HC) Barajasx: Germn Reviriego Jan, Cristina Montero Garca, Ana Isabel Sanz Lorente, M a del Pilar Serrano Simarro, Julin Daz Snchez, Irma M a Ramos Gutirrez, Josefa M a San Vicente Rodrguez, Pilar Huelin Martn, M a Inmaculada Gonzlez Garca, Margarita Camarero Shelly, Clarisa Reinares Martnez, Laura Villanova Cuadra, Rosa M a Gmez del Forcallo

When low B12 is found, the next step is usually to confirm the cause

In a randomized clinical trial comparing oral and parenteral therapy, both groups showed similar reductions in mean corpuscular volume and increases in hematocrit at 4 months.11 The present case highlights the causal relationship between vitamin B12 deficiency and generalized skin hyperpigmentation, an association that presents a wide variety of dermatological manifestations

PubMed searches return zero combined trials as of early 2026

Local administration of methylcobalamin and lidocaine for acute ophthalmic herpetic neuralgia: A single-center randomized controlled trial