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Mitochondrial biology and dysfunction: core mechanisms Physiological functions of mitochondria Mitochondria, as double-membraned organelles characterized by distinct structural and functional domains including the outer mitochondrial membrane (OMM), inner mitochondrial membrane (IMM), intermembrane space (IMS), and mitochondrial matrix, play a multifaceted role in cellular physiology

137,138 ER chaperones can be grouped on the basis of their function in protein folding and quality control: ATP-dependent chaperones (e.g., BiP/HSPA5/GRP78), lectin chaperones (calnexin, calreticulin), and protein disulfide isomerases (PDIs) (Fig

10.1016/j.lfs.2020.118460 92 LiuJ.KangR.TangD

Methylation of either of the nitrogen atoms in the imidazole rings of the histidine residues 6, 13 and 14 prevents formation of bridging histidine moieties

10.1186/s12943-025-02372-0 129

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