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Personality profiling of the modern surgical trainee: insights into generation X

To match the peak steady-state concentration, the loading dose can be calculated from equation (13): TARGET CONCENTRATION INTERVENTION: APPLICATION OF PHARMACOKINETICS & PHARMACODYNAMICS TO DOSE INDIVIDUALIZATION The basic principles outlined above can be applied to the interpretation of clinical drug concentration measurements on the basis of three major pharmacokinetic variables: absorption, clearance, and volume of distribution (and the derived variable, half-life)

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New England Journal of Medicine (2025) 4

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[DOI] [PMC free article] [PubMed] [Google Scholar] 418.Purwana I., Liu J.J., Portha B., Buteau J