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Another limiting factor includes the implementation of dietary therapy, which many families find very tedious to implement, so families should be counseled before implementing dietary therapy in order to obtain desired results [96, 171] (Table 2 )

Also, since interacts with several molecular pathways [4,5,27,28,41,45,56,57,73,74,75,76], it is conceivable that BPC 157 largely interacts with NO-system in various models and species [15] and may induce NO-release of its own, even in the condition where L-arginine is not working [94]

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23 In addition, these peptides may indirectly regulate AMPK activity to promote mitochondrial efficiency and FoxO transcription factors (Table 2)