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Excessive stimulation of NMDA receptors by glutamate results in abnormally high amounts of intracellular calcium

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Patients with kidney disease need dose adjustmentsstandard 75mg twice daily drops to 75mg once daily when creatinine clearance falls below 60 mL/min

doi:10.1038/nchembio711 Fuchs Y, Steller H (2011) Programmed cell death in animal development and disease

Lancet 390 (10114), 27692778

Increased Vitality: Low levels of glutathione can lead to fatigue and decreased energy levels