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Although the data are conflicting, it appears that the administration of charcoal may interfere with drug absorption, with up to 96% of the drug adsorbed on to the charcoal

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The limited tumor-targeting specificity, inability to transport the sensitizers deeply intratumorally, and the deteriorating tumor microenvironment limit their anti-tumor effectiveness

It is also involved in DNA synthesis, protein and prostaglandin synthesis, amino acid transport, metabolism of toxins and carcinogens, immune system function, and enzyme activation