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Actin is a fundamental structural protein in cells, critical for cell movement, tissue structure, and wound healing

And I'm guessing that for women it's the combination of growth hormone secretag plus something like

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Diagnosis is made by the finding of a diffuse, smooth, firm goiter in a young woman, with strongly positive titers of TG Ab and/or TPO Ab and a euthyroid or hypothyroid metabolic status

The connecting theme across these observations is tissue repair and protection, particularly in contexts of mucosal, vascular, muscular, and tendinous injury

Tumor-infiltrating monocytes/macrophages promote tumor invasion and migration by upregulating S100A8 and S100A9 expression in cancer cells