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Fatigue can be categorized as chronic when it persists for more than 6 months and is unrelieved by rest, often without a clear underlying medical cause

SARS-CoV-2 spike protein interacts with and activates TLR41

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Nitric oxide signals the blood platelets to remain smooth and non-sticky, reducing their tendency to aggregate and form the microclots that are so heavily implicated in the mechanisms of Long COVID

Ye Z, Gastfriend BD, Umlauf BJ et al (2022) Antibody-targeted liposomes for enhanced targeting of the blood-brain barrier