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Trends in use over time are complicated by multiple means of acquiring the drug: through administration by physicians in clinics and hospitals and by caregivers using over-the-counter formulations at home

PubMed, Bhandage, Amol K., and Antonio Barragan

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Since ATP7B is involved in CP synthesis and copper excretion, its missense mutations often result in copper accumulation within the liver, causing severe hepatotoxicity and systemic symptoms ( In WD patients, the absence of ATP7B expression in IECs leaves copper absorption unaffected

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Ding L, Zhang FB, Liu H, Gao X, Bi HC, Huang L, et al