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Genetic suppression of IKK2/NF-B in astrocytes inhibits neuroinflammation and reduces neuronal loss in the MPTP-Probenecid model of Parkinsons disease

(2011), Pathogenic effects of novel mutations in the P-type ATPase ATP13A2 (PARK9) causing Kufor-Rakeb syndrome, a form of early-onset parkinsonism

Protects against oxidative stress*

However, there's a challengelong-chain fatty acids cannot cross the mitochondrial membrane on their own

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The overexpression of Parkin in cortical neurons has been demonstrated to increase the levels of PGC-1 and mtDNA copy number (Zheng et al., 2017)