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There is some research to suggest it can cause issues in people who have kidney problems

If you think your supplement is causing constipation, there are things you can do about it
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[DOI] [PubMed] [Google Scholar] Galli LM, Barnes TL, Secrest SS, Kadowaki T, Burrus LW

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When the thigh stops working as well After extended use, some people notice that a particular thigh zone seems to absorb medication less effectively
