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Almost all drugs (or their metabolites) are eventually excreted, but for many, excretion occurs only some time after they have been metabolized to inactive products Induction and inhibition of drug metabolism A large number of drugs alter their own metabolism and the metabolism of other drugs either by inducing the synthesis of larger amounts of the metabolizing enzymes (usually P450 enzymes in the liver) or by inhibiting those enzymes

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By supplementing non-reduced lysates with oxidized glutathione (GSSG), they confirmed the inducibility of the modification

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[DOI] [PubMed] [Google Scholar] 28.Thomas B, Ramesh A, Suresh S, Prasad BR