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In animals, the most pronounced effect of ZEN and its metabolites is dysfunction of the reproductive system due to its estrogenic properties (Ropejko and Twaruek, 2021)

Correlation analysis indicated that lactate levels were significantly associated with mean pulmonary artery pressure, pulmonary vascular resistance, and N-terminal pro-B-type natriuretic peptide [214]

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In particular, the selection of an appropriate control or comparison group is required to determine, all other things being equal, whether a treatment is efficacious for a given illness, whether it has benefits over other therapies for the illness, and how it can achieve its effects