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Size, surface charge, and flexibility are important determinants for cellular internalization of NPs, with lipid-based NPs being more readily internalized than rigid silica or metal-based NPs ( The complexity of the physiological and pathophysiological barriers encountered during the systemic delivery of NPs to the brain complicates the development of successful NP-based therapeutics ( The review intends to give a broad and impartial presentation of the present status of nanoparticle-mediated drug delivery approaches for CNS disorders

Microglia in neurodegenerative diseases: mechanism and potential therapeutic targets

J., Zhai, J

In reproductive tissues, this results in faulty cell signaling, damaged gamete DNA, and disrupted tissue function, all of which are important for fertility

These agents are particularly useful as add-on therapies but may also suffer from incomplete CNS penetration and systemic side effects such as hypertension and insomnia due to their off-target activity