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However, when the body lacks the necessary cofactors to drive these reactions, the entire system begins to slow down, leading to a cascade of systemic dysfunction

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2002 PMID: 11811170 Anderson, D.G., Izzo, M.W., Hall, D.J, Vaccaro A.R.., Hilibrand, A., Arnold, W., Tuan, R.S., Albert, T.J.: Comparative Gene Expression Profiling of Normal and Degenerative Discs: Analysis of a Rabbit Annular Laceration Model

Currently, the disease may be approached either pharmacologically or non-pharmacologically