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Methotrexate (MTX) is an antimetabolite that reversibly binds dihydrofolate reductase, inhibiting the conversion of dihydrofolate to tetrahydrofolate and thus disrupting DNA synthesis, repair, and cellular replication

Some doctors call it albuminuria and some call it chyluria

Meaningful visible changes to firmness and fine lines: 4-8 weeks

Approval for treatment is not guaranteed

Patient education initiatives are crucial to empower individuals to advocate for proper B12 deficiency diagnosis and treatment

Therefore, cell replenishment, inhibition of inflammatory response and oxidative stress may contribute to the treatment of IDD (Zhang et al., 2020)