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Alcohol consumption, especially in significant amounts, has been shown to decrease growth hormone secretion, increase the stress hormone cortisol (which is catabolic, meaning it breaks down muscle tissue), and interfere with insulin sensitivity

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[DOI] [PMC free article] [PubMed] [Google Scholar] 51.Ito T., Tokura Y

DOI: Published: Publisher Name: Springer, Cham Print ISBN: 978-3-031-24777-4 Online ISBN: 978-3-031-24778-1 eBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)

In the matrix, multiple enzymes work together to degrade misfolded, damaged, and oxidized proteins, as well as to turnover some metabolic enzymes, forming the CLPXP complex and Lon protease homolog (LONP)