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The degradation of red blood cell hemoglobin through the alternative pathway was thought to be responsible for the so-called missing blood syndrome [6]

In epilepsy research, although there are several reports illustrating that enhancement of GABA-mediated inhibitory neurotransmission [139] and ion channel inhibition [140] are involved in the convulsive effects of VPA, there is also prior work supporting that HDACs serve as vital upstream regulators of molecular targets associated MoAs such as ion channel [164]

Biochim Biophys Acta 1472(3):643650 Garcia-Alcantara F, Murillo-Cuesta S, Pulido S, Bermudez-Munoz JM, Martinez-Vega R, Milo M, Varela-Nieto I, Rivera T (2018) The expression of oxidative stress response genes is modulated by a combination of resveratrol and N-acetylcysteine to ameliorate ototoxicity in the rat cochlea

In conclusion, OSAHS may influence estrogen production through various mechanisms, with sleep deprivation likely being the predominant factor

All authors have read and agree with this paper

Each dimer contains two active sites with independent activities