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Karlsen A, Paur I, Bohn SK, Sakhi AK, Borge GI, Serafini M,

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After exposure cells were lysed and RNA was isolated using the RNA isolation kit (Macherey Nagel GmbH, Dren, Germany)

These compounds bind to NCOA4, disrupting its interaction with FTH1 and inhibiting NCOA4-dependent ferritin autophagy, thereby reducing intracellular free iron (Fe 2 ) levels and suppressing ferroptosis ( 4.2 Lipid peroxidation-related biomarkers and OA 4.2.1 Malondialdehyde (MDA) and 4-Hydroxynonenal (4-HNE) MDA and 4-HNE are key end products of lipid peroxidation and significant markers of ferroptosis