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EMBO Rep 23(8):e52280 Tschuck J et al (2023) Farnesoid X receptor activation by bile acids suppresses lipid peroxidation and ferroptosis

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Schurr and Gozal demonstrated that during neuronal activation, NADHproduced via mLDHacts as an endogenous ROS scavenger, neutralizing oxidative stress induced by glutamate excitotoxicity and thereby conferring neuroprotection (Schurr and Gozal, 2011)

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In addition to TZDs, microglia activation and M2 polarization following brain stroke could be induced by metformin, a glucose-lowering agent belonging to biguanides [76]