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Furthermore, it was discovered that indenopyrazole, without any impact on HIF-1 protein synthesis or heterodimerization, significantly reduced the transcriptional activity of HIF-1 [81,110]

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Thus, the mechanisms of MNP action have a reproducible architecture across different organs but with organ-specific accents: impaired barrier functions and neuroinflammation in the CNS, hormonal dysregulation and transgenerational effects in reproduction, fibrosis and mitochondrial dysfunction in the heart and kidneys, and microbiota and metabolic disruption in the digestive tract and liver

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