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These are not rare anecdotes they appear consistently across patient forums and in clinical observations

Non-synonymous to synonymous substitutions ( K a / K s ) ratio indicates the evolutionary history and direction of selection ( K a / K s 1 implies positive or Darwinian selection ( K a / K s ratio of all gene pairs was found to be below 1 indicating the influence of purifying selection in the evolution of glyoxalase genes among Arabidopsis , rice, soybean, and Medicago ( Table 4 )

Samples were separated by SDS-PAGE and transferred to a PVDF membrane (Millipore, Billerica, MA)

Powers et al

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78 MacKenzieE