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Mitochondria is a cellular organelle often referred to the "powerhouse" of the cell, regulating a range of functions from energy generation, metabolism and cell survival

One of the most critical signaling axes in embryonic development is the Wnt pathway, which regulates cell self-renewal, differentiation, proliferation, and migration [90]

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Adipocyte-derived kynurenine promotes obesity and insulin resistance by activating the AhR/STAT3/IL-6 signaling

However, the role of nutritional supplements in CIPN remains controversial due to the varied mechanisms of neuropathy induced by different antineoplastic drugs and the presence of complex drug interactions, and further research on such drugs is necessary in the future

This GHRH-ghrelin synergy is well-documented in basic endocrine physiology