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Description
Structure-based virtual screening and functional validation of potential hit molecules targeting the SARS-CoV-2 main protease

Collett-Solberg PF, Ambler G, Backeljauw PF, Bidlingmaier M, Biller BMK, Boguszewski MCS, Cheung PT, Choong CSY, Cohen LE, Cohen P, Dauber A, Deal CL, Gong C, Hasegawa Y, Hoffman AR, Hofman PL, Horikawa R, Jorge AAL, Juul A, Kamenicky P, Khadilkar V, Kopchick JJ, Kristrom B, Lopes MLA, Luo X, Miller BS, Misra M, Netchine I, Radovick S, Ranke MB, Rogol AD, Rosenfeld RG, Saenger P, Wit JM, Woelfle J

Vitamin B12 is essential for supporting oxygen transport throughout the body by aiding in red blood cell production

10 nM FITC-labeled sCT(2232) was used as the peptide probe for CTR ECD binding, while 10 nM FITC-labeled AC413(6-25) with Y25P mutation was used as the peptide probe for all RAMP ECD-CTR ECD fusion proteins

71 Tjaard Hoogenraad, also from the Netherlands, extended the report on the benefit of zinc therapy at this meeting and in later publications

We optimized MRM conditions to ensure maximum signal and sensitivity for each analyte
