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Mutations in the AIRE gene cause autoimmune polyendocrinopathy, a condition where multiple organs come under immune attack simultaneously

Major progress in our understanding, based on increasingly more precise identification of cell types and intercellular signaling as well as of intracellular molecular cues at play in SSc physio-pathology has spurred enthusiasm in the scientific community and has led to the recent approval of therapeutic agents that may alter the disease course

[DOI] [PMC free article] [PubMed] [Google Scholar] [106].Crack PJ, Taylor JM, Flentjar NJ, de Haan J, Hertzog P, Iannello RC, Kola I, Increased infarct size and exacerbated apoptosis in the glutathione peroxidase-1 (Gpx-1) knockout mouse brain in response to ischemia/reperfusion injury

Knockdown of GLP-1 receptors in vagal afferents affects normal food intake and glycemia

Cell Res 30:146162

While human clinical trials remain limited, the breadth and consistency of preclinical evidence combined with extensive user reports provides substantial insight into this peptides therapeutic potential