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In 1796, Edward Jenner, an English rural general practitioner, experimented with inoculation from a milkmaids cowpox pustule to a healthy youngster, who subsequently proved resistant to smallpox by variolation (see Chapter 1)

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doi: 10.1038/mp.2011.71, PMID: [DOI] [PMC free article] [PubMed] [Google Scholar] Knox D., Perrine S

doi: 10.1038/nrendo.2013.89

This profile suggests potential implications of the peptide in studies conducted in laboratory settings aiming to dissect noncanonical, Erk5-centered pathways downstream of IGF-1-derived products, separate from the typical IGF-1Akt proliferative axis

A positive correlation between changes in behavior and GSH/GSSG ratio was additionally observed [70]